From the comments in the blog —
Exchange 2007 / Server 2008 have the issue where if IPv6 is enabled, Outlook Anywhere doesn’t work. Do you know if SBS 2008 has same issue? I would assume it does? The only way to resolve is to disable ipv6. And to do that you have to untick the ipv6 box as well as disable ipv6 via registry.
No, SBS 2008 does not have this issue. Again, let me make myself very clear. Ensure that you do NOT untick IPv6 on SBS 2008.
http://technet.microsoft.com/en-us/library/cc671176.aspx This doesn’t apply to SBS. I’ll get the details as I don’t remember the exact technical reason it doesn’t apply whether it’s due to Exchange being on the Domain Controller and thus being able to see itself, or if it’s the magic done but the SBS 2008 team but no, do not disable ipv6 on SBS 2008. Outlook Anywhere works with IPv6 enabled and the Server needs it enabled as well.