A quick look on the internet shows an increasing amount of people reporting an error 550 “Sender address is invalid [route]:” with bouncing emails. This is new as of August 2015. No one knows what the error means.
It seems for Aussie clients with this recent issue, the likely fault is with TPP Wholesale whom upgraded security/mail filtering on their network and they are now aware of the issue and are working to resolve for multiple clients.
They have old webmail service lines / interbnal routes existing in Webcentral accounts which is creating conflicts.
Webcentral, MelourneIT, TPP etc are all now the same company.
If you need this resolved, contact TPP.