A couple of interesting posts I came across.
First up is a way to work with System Center Configuration Manager using PowerShell. http://blogs.technet.com/mniehaus/archive/2009/04/07/fun-with-configmgr-2007-and-powershell.aspx
Some of the System Center family have PowerShell support but not Config Manager. Hopefully this will be corrected in the next release.
The second post was from Jonathan – a UK User Group member – on working with the registry and using the functions supplied by PowerShell MVP Shay Levy - http://jonathanmedd.blogspot.com/2009/04/putting-shays-powershell-registry.html