The Patch Tuesday updates installed successfully on both work PCs and no issues have been discovered in early testing.  This is a large group of updates (76MB) including Office 2010 and Framework.  These updates take several minutes to update. The Framework update is lengthy and may even seem to hang, so users should be patient.  It will probably take about 20-30 minutes to install and a reboot should be performed as prompted so that all changes become properly effective.

Microsoft Security Bulletins – April 2011

ISC provides excellent summary (two bulletins are rated PATCH NOW)